Your children are not your children They are the offspring of life’s longing for itself. They come through you but not from you And though they are with you, they belong not to you.
You may give them your love, but not your thoughts For they have their own thoughts. You may house their bodies, but not their souls; For, their souls rest in the house of tomorrow Which you cannot visit; not even in your dreams.
You may strive to be like them, But seek not to make them like you, For life goes not backwards; Nor tarries with yesterday.
You are the bows, from which, your children, As living arrows, are sent forwards. The archer sees the mark upon the path, of the infinite; And he bends you with his might, That his arrows may go, swift and far.
Let your bending in the archers hand be for gladness, For as he loves the arrow that flies, So he loves also the bow that is stable…
A mechanic was removing the cylinder heads from the motor of a car when he spotted the famous heart surgeon in his shop, who was standing off to the side, waiting for the service manager to come to take a look at his car.
The mechanic shouted across the garage,"Hello Doctor!! Please come over here for a minute."
The famous surgeon, a bit surprised, walked over to the mechanic.
The mechanic straightened up, wiped his hands on a rag and asked argumentatively, "So doctor, look at this. I also open hearts, take valves out, grind 'em, put in new parts, and when I finish this will work as a new one. So how come you get the big money, when you and me is doing basically the same work? "
The doctor leaned over and whispered to the mechanic.....
. . . . . .
He said: "Try to do it when the engine is running".
The molecular scaffold is an oft-cited concept in medicinal chemistry suggesting that the definition of what makes a scaffold is rigorous and objective. However, this is far from the case with the definition of a scaffold being highly dependent on the particular viewpoint of a given scientist. It follows, therefore, that the definition of scaffold hopping and, more importantly, the detection of what constitutes a scaffold hop, is also ill-defined and highly subjective. Essentially, it is agreed that scaffolds should be substantially different from each other, although significantly similar to each other, to constitute a hop. In the latter, the scaffolds must permit a similar geometric arrangement of functional groups to permit the mode of action. However, this leaves the paradox of how to describe both scaffold similarity and dissimilarity simultaneously. In this paper, the current statuses of scaffolds and scaffold hopping are reviewed based on published examples of scaffold hopping from the literature. An investigation of the degree to which it is possible to formulate a more rigorous definition of scaffolds and hopping in the context of molecular topologies is considered. These techniques are adapted from chemoinformatics to be applied in the design of new medicinal compounds.